Mefloquine HCl

Synonyms: Mefloquin hydrochloride

Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.

Mefloquine HCl Chemical Structure

Mefloquine HCl Chemical Structure

CAS No. 51773-92-3

Purity & Quality Control

Mefloquine HCl Related Products

Biological Activity

Description Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03893097 Completed
Schistosoma Haematobium|Schistosoma Mansoni
Institute of Tropical Medicine Belgium|Institut de Recherche en Santé de Surveillance Épidémiologique et de Formation (IRESSEF)
October 14 2019 Phase 3
NCT02895568 Completed
Plasmodium Falciparum
University of Oxford|Worldwide Antimalarial Resistance Network|Mahidol University
September 16 2016 --
NCT02524444 Completed
Malaria in Pregnant HIV + Patients
ORIYOMI OMOTOYOSI AKINYOTU|University of Ibadan
September 2015 Phase 1
NCT01082718 Withdrawn
Malaria|Pregnancy
Centers for Disease Control and Prevention
March 2010 Phase 2|Phase 3

Chemical Information & Solubility

Molecular Weight 414.77 Formula

C17H17ClF6N2O

CAS No. 51773-92-3 SDF Download Mefloquine HCl SDF Download Mefloquine HCl SDF
Smiles C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (197.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 82 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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